The consensus of ER signatures from the 206 combined breast cancer samples resulted in a list of 36 genes, including NME3, ADCY9, WDR90, IKBKB, SRP14, WWP1, GPR160, ERI2, CDIPT, TCEA3, FLJ10661, S100PBP, GLIS2, FLYWCH2, METRN, TRNAU1AP, RSC1A1, TRIM45, HAGH, FDXR, C16orf52, ZNF720, STK40, SLCO4A1, ELOVL1, ADRM1, PDZK1IP1, CHCHD10, SMCR7L, WDR77, RTN4R, THOC5, HPDL, HENMT1, UQCRH, and MRPL37. The predictive accuracy was 89-93% across the various validation methods (Table 3). This evidence concerns the gene METRN and breast cancer.