In contrast, there was marked KPNA2 staining in the nuclei and cytoplasm of malignant cells in several skin tumors with different prognoses including Bowen’s disease, actinic keratosis, squamous cell carcinoma (SCC), Paget’s disease, Merkel cell carcinoma, and Mycosis fungoides. Here, KPNA2 is linked to actinic keratosis.