Early and lasting downregulation of gria2 expression observed in epilepsy models suggest that it plays a critical role in initiating the epileptogenic cascade, maintaining neuronal hyperexcitability [19,20] and is critical for the pathophysiology of mesial temporal lobe epilepsy (MTLE), the most common form of epilepsy acquired in adulthood [21]. The gene discussed is GRIA2; the disease is epilepsy.