To check whether the mechanisms of inhibition of migration of melanoma cells by L9M peptide were similar to that of lumcorin, the activity of MMP-2, MMP-9 and MMP-14 was examined in B16F1 and SK-MEL-28 cell line incubated for 48h with L9M peptide or its corresponding scrambled peptide. This evidence concerns the gene MMP9 and melanoma.