ACE and Hypertension: Also the recessive model (DD versus II+ID) showed an association with hypertension with an adjusted odds ratio of II+ID 1.79(95% CI: 1.09-2.92) (data not shown in Table 4), indicating that the ACE gene I/D polymorphism appeared strong evidence to support the role of the D-allele and/or DD genotype as a risk factor for hypertension.