ACE and Cerebral ischemia: Acute or chronic pancreatitis, lower end malignant bile duct block, ongoing therapy with nitrates, calcium channel blockers, angiotensin-converting enzyme inhibitors, β-blockers, diuretics, or tricyclic antidepressants, patients with angina pectoris , history of myocardial infarction, or cerebral ischemia; and history of allergy to sulfa drugs.