Due to the fact that we used cell lines harbouring different mutations for oncogenic pathway commonly mutated in CRC (Caco2: APCmut, KRASwt, Pi3Kwt; HCT116: APCwt, ß-cateninmut, KRASmut, Pi3Kmut; SW620: APCmut, KRASmut, Pi3Kwt), we postulate that the dependence of c-Myc protein expression on CIP2A is independent of the presence of mutations in WNT, PI3K/mTor or MAPK-pathways, but this will need to be evaluated further. The gene discussed is CIP2A; the disease is colorectal carcinoma.