Although until now there is no information about the type of macrophages that infiltrate meningiomas, the higher expression levels of CD16 (FCGR3A) found here both at the protein and mRNA levels, together with the increased mRNA levels of CD86, CD32 (FCGR2A) and CD64 (FCGR1A) observed in meningiomas with monosomy 22/del(22q) alone, support an M1 vs M2 polarization of macrophages in this subgroup of meningiomas and consequently also, a more favorable anti-tumoral microenvironment. The gene discussed is FCGR1A; the disease is meningioma.