Overall, meningiomas carrying isolated monosomy 22/del(22q) showed significantly greater numbers of TiMa infiltrating the tumor, together with a more pronounced activation profile of immune cells, as reflected by greater percentages of CD69+ and CD63+ TiMa and/or lymphocytes [22], [23], versus cases with either a diploid or a complex iFISH karyotype. This evidence concerns the gene CD69 and meningioma.