IL-12 enhances the ability of CD8+ T cells to cause the regression of large established tumors by potently stimulating the production of high-levels of IFN-γ, resulting in an increase in the cross-presentation of tumor-antigens and the reversal of suppressive functions of myeloid-derived suppressor cells, alternatively activated macrophages, and dendritic cells (22). Here, IFNG is linked to neoplasm.