Therefore, it seems plausible that GAP-43 and related signaling proteins may provide the link between neurological deficits and the extensive immune dysregulation in autism (Smith et al., 2007; Atladottir et al., 2009; Becker and Schultz, 2010; Patterson, 2011; Garbett et al., 2012; Hsiao et al., 2012; Malkova et al., 2012; Patterson, 2012). This evidence concerns the gene GAP43 and autism.