In addition, cohesin binds to the c-Myc gene locus [82], [91], [92], [93], [94], and c-Myc gene expression is downregulated in various CdLS cells with SMC1A and SMC3 mutations and a zebrafish CdLS model with NIPBL deficiency [83], [95], [96]. Here, SMC1A is linked to Cornelia de Lange syndrome.