It is also notable that the top-ranked pathways for RA and T1D, Measles and IL-2 signaling, show strong support in our analysis only after accounting for enrichment of disease associations within the MHC; the BFs without MHC enrichment are 104 and 11, whereas the BFs are  and  after conditioning on enrichment of the MHC. Here, HLA-C is linked to type 1 diabetes mellitus.