It was recently shown that GPR120-deficient mice develop obesity and reduced insulin signaling, and GPR120 expression is significantly higher in obese humans [127], so the effect of this gene may be similar to the reported T2D association with FTO, in which variants near FTO increase T2D risk through an effect on body weight [128], [129]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.