Thus, to test whether protection from infection in Itgb8 (CD11c-Cre) mice could be due to deletion of the integrin in T-cell subsets, we infected mice lacking integrin αvβ8 on T-cells via expression of CD4-Cre (Itgb8 (CD4-Cre) mice) [11]. The gene discussed is ITGAX; the disease is infection.