TGFB1 and infection: In contrast, we did not observe any differences in pSmad2/3 induction in dendritic cells between control and Itgb8 (CD11c-Cre) mice (Figure S2A and B in Text S1), indicating that the integrin αvβ8-mediated TGFβ activation does not trigger autocrine TGFβ signalling in DCs during early infection.