Thus, to determine the importance of this pathway in promoting TGFβ signalling in CD4+ T-cells during T. muris infection, we analysed T-cell responses in C57BL/6 control mice and mice lacking integrin αvβ8 on DCs (Itgb8 (CD11c-Cre) mice) [11] during infection. Here, TGFB1 is linked to infection.