Thrombins-induced VEGF165 expression in inflammation linked to obesity has also been analyzed: higher levels of VEGF (over 13 ng/mL) were measured in preadipocytes upon thrombin stimulation, highligthing the association of thrombin with neoangiogenesis in atherosclerosis and metabolic syndrome [10]. This evidence concerns the gene VEGFA and obesity due to melanocortin 4 receptor deficiency.