Circulating levels of prolactin, a polypeptide hormone involved in numerous physiological processes including reproduction, are higher among EC patients compared to healthy controls (Levina et al. 2009; Yurkovetsky et al. 2007; Kanat-Pektas et al. 2010), and increased PRLR expression has been noted for endometrial tumors compared to non-cancerous endometrial tissue. This evidence concerns the gene PRLR and endometrium neoplasm.