Barrett and Hamilton [10], in their study of the symptoms of prostate cancer, noted that 70% of the prostate cancer patients in Devon, UK, between the years of 1998 and 2002 had lower urinary tract symptoms (LUTS) and that PSA testing had been performed by a GP in 60% of these cases; in contrast, 10% had undergone their first PSA test performed by a urologist. Here, KLK3 is linked to Familial prostate cancer.