Overexpression of gankyrin abrogated the effect of LBH589-induced reduction of N-cadherin and vimentin, which was in conjunction with the results in Figure 3B. The immunofluorescence results for E-cadherin are shown in Additional file 4: Figure S4, LBH589 markedly increased E-cadherin level in both HCC-LM3 and HepG2 cells. This evidence concerns the gene CDH2 and hepatocellular carcinoma.