Hypomorphic, biallelic mutations in the MRE11, RAD50 and NBN genes are linked to recessive genetic conditions, ataxia telangiectasia like disorder (AT-LD), NBS-like and Nijmegen breakage Syndrome (NBS), respectively, [3-5] some of which are characterized by increased risk of cancer. This evidence concerns the gene MRE11 and Nijmegen breakage syndrome.