In conclusion, although we observed that the RAD50_rs17166050 variant allele is linked to decreased ALL risk (p<0.0009, OR=0.6358 (95%CI: 0.4854-0.8327)), no association of the previously detected mutations in the RAD50 and MRE11 genes has been found. This evidence concerns the gene RAD50 and acute lymphoblastic leukemia.