Two patients were unresponsive to steroids and CYP in combination: one entered remission after treatment with mycophenolate mofetil (2 g/day for 18 months) and the other after treatment with 400 mg × 2/day for 43 months of pentoxifylline, a non-specific phosphodiesterase inhibitor with anti-inflammatory properties [19, 20] which reduces proteinuria in membranous [21] and diabetic nephropathy [22] and slows the GFR decline in CKD [19]. The gene discussed is PPIG; the disease is diabetic kidney disease.