A high predictive value of outcome of HMW protein excretion has been observed in other types of GN; IgG in glomerulonephritis [23, 24], idiopathic membranous nephropathy [25–27], crescentic [28] and noncrescentic IgA nephropathy [29, 30] with different cutoffs for each type of GN; IgM (MW: 900 kDa) in ANCA-associated renal vasculitis [31] and type 2 diabetic nephropathy [32]. The gene discussed is CD40LG; the disease is ganglioneuroma.