The increasing awareness of the molecular mechanisms underlying tumor angiogenesis in RCC parallels the development of novel antiangiogenic agents, mainly directed against VEGF-A, platelet-derived growth factor (PDGF) receptors (PDGFRs), and VEGF receptor-2 (VEGFR-2), with a list of novel targets currently in course of evaluation. The gene discussed is VEGFA; the disease is renal cell carcinoma.