Finally, lysophosphatidic acid (LPA), a bioactive phospholipid present in high levels in the ascites of ovarian cancer patients and produced by ovarian cancer cells, signals through cell surface bound G-protein dependent receptors and impose diverse affects on ovarian cancer cells which includes increased transcriptional regulation of vascular endothelial growth factor (VEGF), uPA, IL-6, and IL-8 (47, 48). This evidence concerns the gene VEGFA and ovarian cancer.