Given that deregulation of PI3 kinase and the downstream AKT pathway has been demonstrated in ovarian cancer (125, 126), and high levels of p38 and an increase in the ratio of phosphorylated EGFR and phosphorylated JNK were associated with bad prognosis in ovarian cancer patients (124), it seems that the proteomic profile of the ascites environment may imitate the protein expression profile of the original tumors (2). This evidence concerns the gene MAPK8 and ovarian cancer.