Malignant ascites has been shown to also contain GD3 ganglioside, which inhibits the innate natural killer T (NKT) cell activity (32), while MUC16 expressed on the surface of ovarian cancer cells has been shown to inhibit the interaction of ovarian cancer cells with natural killer cells thus providing protection to ovarian cancer cells from host immunity (33). This evidence concerns the gene MUC16 and ovarian cancer.