Inhibition of the mevalonate pathway blocks the synthesis of isoprenoid molecules (farnesyl pyrophosphate and geranylgeranyl pyrophosphate) that facilitate post-translational modification and activate Ras, Rac, and Rho GTPases molecules contributing to tumor proliferation (Zhuang et al., 2005; Solomon et al., 2009; Gorin et al., 2012). The gene discussed is AKT1; the disease is neoplasm.