SOD1 and amyotrophic lateral sclerosis: Cytoplasmic inclusions positive for both ubiquitin and SOD1 were identified in lower motor neurons and anterior horn cells at post mortem in G72C (Stewart et al., 2006) and H80A (Alexander et al., 2002) ALS patients, providing evidence that mutations affecting the region of the zinc-binding loop of SOD1 cause protein instability, incorrect dimerisation of SOD1 and aggregation of the SOD1 protein.