Our data are consistent with previous reports indicating that skin, which typically heals with scar, exhibits a high ratio of TGF-β1 to TGF-β3; whereas OM, which heals with minimal scar, and fetal tissue, which heals with no scar, exhibit significantly lower ratios of TGF-β1 to TGF-β3 (Cowin et al., 2001; Ferguson and O’Kane, 2004; Occleston et al., 2008a; Occleston et al., 2011; Schrementi et al., 2008). Here, TGFB3 is linked to ocular melanoma.