Most of the FMRP targets encode for proteins involved in cellular movement, migration and motility, adhesion and EMT such as Vimentin (Vim), E-cadherin (Cdh1), Microtubule associated protein 1B (Mtap1b), Occludin (Ocln), or involved in cancer signal transduction such as estrogen receptor 1 alpha (Esr1), epidermal growth factor receptor (Egfr), notch gene homologue 1 (Notch 1) or transcription factors such as twist homologue 1 (Twist1), fibronectin 1 (Fn 1) and zinc finger E-box binding homoeobox2 (Zeb2). The gene discussed is TWIST1; the disease is cancer.