The percentage of samples expressing high levels of FMRP correlates with high tumour grade (G3) and high proliferation index (Ki67) (Fig 1C), both of them indicators of poor prognosis (Elston & Ellis, 1991; Fitzgibbons et al, 2000; Goldhirsch et al, 2001). The gene discussed is FMR1; the disease is neoplasm.