The DURABLE trial (assessing the DURAbility of Basal versus Lispro mix 25 insulin Efficacy) was designed to study the efficacy, safety, and durability of two starter insulin regimens (twice-daily insulin lispro mix 75/25 [LM75/25, 75 % insulin lispro protamine suspension, 25 % insulin lispro] versus once-daily insulin glargine [GL]) in a large, diverse cohort of patients with type 2 diabetes [4, 5]. This evidence concerns the gene INS and type 2 diabetes mellitus.