To study the effect of DKK1 and DKK2 on tumor angiogenesis and proliferation, we injected either adenoviral-mDKK1 (Ad-DKK1) or -mDKK2 (Ad-DKK2) constructs into B16F10 melanomas that had been established in syngeneic C57BL/6 mice. Here, DKK2 is linked to neoplasm.