DKK2 and melanoma: On the contrary, melanoma growth was accelerated in DKK2 Tg mice versus wild-type controls (3,844 ± 252 vs. 2,874 ± 140 mm3, respectively; p < 0.001) and mouse survival was significantly reduced in DKK2 Tg mice (Fig. 2b, right panel; p < 0.001).