PFN1 and Glucose intolerance: Recently, Romeo et al. reported that high-fat diet (HFD) up-regulated the expression of profilin-1 in both stromal vascular cells and adipocytes of white adipose tissue (WAT) and pfn heterozygote mice (PfnHet) displayed near normalization of HFD-induced glucose intolerance and the release of pro-inflammatory cytokines, suggesting that profilin-1 plays an bran-new role in modulation of immune homeostasis within the WAT microenvironment[30].