Moreover, recent studies have found that necroptosis is also the predominant damage mechanism in ischemia/reperfusion damage in the kidney[42,49], in summary indicating that both brain and kidney are organs where therapeutic strategies aiming to interfere with the necroptotic actions of HtrA2/Omi and UCH-L1 may be worthwhile options to consider for the future, e.g. with regard to stroke or kidney failure. Here, HTRA2 is linked to stroke disorder.