COL4A3 and renal fibrosis: Zeisberg et al., 2008, designed and conducted a landmark experiment that first confirmed the contribution of EndMT in renal fibrosis in three mouse models, unilateral ureteral obstruction (UUO; a model used to study progressive tubulointerstitial fibrosis), streptozotocin- (STZ-) induced diabetic nephropathy, and α3 chain of collagen type 4 (COL4A3) knockout mice (a mouse model for Alport syndrome).