On the other hand, a growing body of studies reported that cytokines might also directly modulate GABAergic transmission [115]: interleukin 1β was found to depress GABA release in a model of autoimmune encephalitis [120] and to potentiate GABAergic transmission in CA1 [121] or in hypothalamic neurons [122]; both interleukin 6 and interleukin 1β were seen to reduce GABA- and Gly-mediated currents in the spinal dorsal horn [123]; tumor necrosis factor α was shown to promote GABAAR endocytosis in hippocampal neurons thus weakening the inhibitory synaptic strength [124]. This evidence concerns the gene IL6 and autoimmune encephalitis.