According to another measure of pSNV importance, 1,427 direct pSNVs replace the central phosphorylated residue and thus disrupt phosphorylation; such mutations are under-represented on the whole, although frequently seen in known cancer genes such as TP53 and CTNNB1 (79 cancer genes, p = 4.2e − 18, Fisher's exact test). This evidence concerns the gene TP53 and cancer.