Although the molecular components that Rab22A brings into phagosomes to modulate their function remains unknown, it has been described that during infection with Legionella, the VipD effector protein prevents the binding of Rab5 and Rab22a to critical downstream effectors such as Rabaptin-5, Rabenosyn-5 and EEA-1 causing a block in lysosomal degradation. Here, RAB22A is linked to infection.