APOE and Alzheimer disease: Of the co-variates, the interaction of time by diagnostic status and APOE ε4 carrier status were significant for both entorhinal cortex atrophy (diagnostic status x time: β-coefficient = -0.007, SE = 0.002, p-value = 0.0005; APOE ε4 carrier status x time (β-coefficient = -0.004, SE = 0.002, p-value = 0.03) and AD-vulnerable ROI atrophy (diagnostic status x time: β-coefficient = -0.006, SE = 0.002, p-value = 0.0003; APOE ε4 carrier status x time (β-coefficient = -0.003, SE = 0.001, p-value = 0.02).