F2RL1 and irritable bowel syndrome: As shown in Table 3 and Figure 4, relative quantification of PAR-2 mRNA in the colonic mucosa revealed that rats undergone PI-IBS had higher levels of PAR-2 mRNA (1.485 ± 0.537) than that of normal rats (0.634 ± 0.224) (P< 0.05).