Interestingly, the suppression of AKT downstream signaling monitored by pPRAS40 (52%) and pS6 (42%) was only observed in the PI3KCA mutant PDGCX model (SGC100), but not in the PTEN null PDGCX model (SGC020), correlating with AZD5363 anti-tumor efficacy. The gene discussed is AKT1; the disease is neoplasm.