IGHE and schistosomiasis: In contrast to the Th1-protective mechanism in the mouse, protection in humans from schistosomiasis-endemic communities is linked with type-2 responses and is positively correlated with specific IgE levels [52], [53], [54] and Th2 cytokines [39], [55]; protection is thought to be effected by eosinophils against the incoming larvae using antibody-dependant cellular cytotoxicity [3], [20], [56], [57], [58].