Sequencing of the DENND1A gene from patients with PCOS identified eight SNPs within the coding region of DENND1A. One of these SNPs is a missense SNP (rs189947178) that gives rise to an amino acid change (alanine to aspartic acid) and therefore potentially could be associated with the PCOS pathogenesis. Here, DENND1A is linked to polycystic ovary syndrome.