Our investigations have shown that the immunoexpression of HIF-1α, CA9, Ki67, CD31, pVEGFR1, VEGFR1 and -2, pPDGFRα and -β in the primary tumors of metastatic ccRCC patients might support the prediction of a good response to sunitinib treatment. This evidence concerns the gene PECAM1 and nonpapillary renal cell carcinoma.