For instance, a study of candidate genes for AD in a large French sample found that rs6265 was not associated with AD risk (nor was rs1157659, rs11030108, rs908867, rs1491850), however SNP rs11030094 was significantly associated with AD (p=.01, odds ratio .91), even when adjusted for other AD risk genes such as APOE, CLU, CR1, and PICALM [35]. This evidence concerns the gene CLU and Alzheimer disease.