RB1 and cancer: Recently, the regulatory network of TROP2 was seriously studied by S Alberti et al [23], they found that TROP2 expression was closely related with several important transcription factors such as TP63/TP53L, ERG, GLIS2, FOXM1 and so on, and TROP2 upregulation was shown to stimulate the cancer related downstream targets including Jun, NF- kB, Rb, STAT1 and STAT3.