Parkin et al. and zur Hausen reported that up to 25% of oral cancer is associated with HPV infection [1,35] Hafkamp et al. [36] suggested that HPV is more commonly detected in young patients with head and neck cancer and it has been related to down-regulation of pRb, overexpression of p16INK4A and wild-type p53. Here, CDKN2A is linked to lip and oral cavity carcinoma.