The latter possibility of a higher metabolic pressure on the clock in SHR is supported by the previously demonstrated relationship between hypertension and hepatic physiology, as manifested by the metabolic aberrances of SHRs [32] and the differences in the expression of metabolism-relevant proteins in SHR liver [52], as well as by the different sensitivity of the metabolic markers to RF, as discussed below. Here, CLOCK is linked to hypertensive disorder.