A correlates study found a lower risk of HIV-1 infection in RV144 vaccine recipients whose plasma IgG bound an antigen comprising the gp120 variable regions 1 and 2 (V1V2) attached to the C-terminus of a murine leukemia virus (MLV) gp70 scaffold (gp70-V1V2) [32]. The gene discussed is EMB; the disease is HIV-1 infection.