TGFB1 and glomerulosclerosis: Because TGF-β induces podocyte apoptosis and podocyte apoptosis is a mechanism for the podocyte depletion that leads to progressive glomerulosclerosis in both Dicerfl/fl:NPSH2-Cre and Alb/TGF-β transgenic mice, we determined the frequency of target genes that were associated with apoptosis in TGF-β-regulated and random control miRNAs.