S100A8 and peptic ulcer disease: Since Marshall and Warren reported in 1984 [8] a curved bacillus that may serve as the causal factor of gastritis and peptic ulceration, a strong link has been established between Helicobacter pylori especially the CagA (a product of cytotoxin associated gene A) positive strains, and a diverse spectrum of diseases, such as, acute and chronic gastritis, peptic ulcer disease, gastric cancer, mucosa-associated lymphoid tissue (MALT) lymphoma [9].