CYBB and Parkinson disease: Since inhibition of microglial cells by minocycline treatment increased the susceptibility of gp91phox-/- 6-OHDA lesioned mice to develop PD and exacerbated the pro-inflammatory response induced by the neurotoxin, our results further strengthen the hypothesis that Nox2 adds an essential level of regulation to signaling pathways underlying the inflammatory response after PD induction.