In regards to overall survival, larger tumor size (≥4 cm) (P<0.001), vascular invasion (P<0.001), intrahepatic metastasis (P<0.001) and the histologic groups of cHC-CC and EpCAM(+)/K19(+) HCC (P = 0.002) were revealed as adverse prognostic factors (Table 4). Here, CXCR1 is linked to hepatocellular carcinoma.