Univariate analysis revealed that larger tumor size (≥4 cm) (P = 0.006), history of preoperative treatment (P<0.001), vascular invasion (P<0.001), intrahepatic metastasis (P<0.001), and the histologic groups of cHC-CC and EpCAM(+)/K19(+) HCC (P = 0.004) were adverse prognostic factors affecting disease-free survival after resection. The gene discussed is KRT19; the disease is cholangiocarcinoma.