EPCAM and hepatocellular carcinoma: Moreover, cHC-CCs have been reported to exhibit aggressive characteristics of greater lymph node involvement, vascular invasion, and worse prognosis than HCC.[13], [25]–[27] The present study also revealed that cHC-CCs show more aggressive characteristics of larger tumor size, more frequent vascular invasion and poorer differentiation than EpCAM(−)/K19(−) HCCs.