For overall survival, larger tumor size (≥4 cm) (HR = 3.448, P = 0.008), vascular invasion (HR = 7.135, P = 0.009), and the histologic groups of cHC-CC and EpCAM(+)/K19(+) HCC (P = 0.034) were shown to be independent prognostic factors on multivariable analysis (Table 5). Here, CXCR1 is linked to hepatocellular carcinoma.