To demonstrate that SOX9, SOX10 and P-CREB are actually recruited on meloe promoter in vivo, a ChIP experiment focusing on a restricted promoter region bearing SOX and CREB binding sites (Figure 4A) was conducted on three tumour cell lines: M113 cell line strongly expressing meloe, and two non melanoma cell lines poorly expressing meloe (Meso163 and SW480). This evidence concerns the gene CREB1 and neoplasm.