On the contrary, most of the CpG motifs of this region, including that of the CREB binding site, are hypermethylated in mesothelioma cells (100% in Meso45 and 77% in Meso163), and in colon carcinoma cells (64% in SW480 and 85% in SW707). The gene discussed is CREB1; the disease is colon carcinoma.