Based on the negative correlation between HDAC4 levels and various metabolic and inflammatory markers (Table 5) and given the importance of stress kinases such as JNK, IKKβ in obesity and insulin resistance, we sought to determine whether overexpression of HDAC4 has an effect on JNK and NF-κB activation. This evidence concerns the gene IKBKB and obesity due to melanocortin 4 receptor deficiency.